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A microneedle device for rapid dermal interstitial fluid sampling.

Andy H Hung1, Netra U Kamat2, Abel Bermudez1,3

  • 1Department of Radiology, School of Medicine, Stanford University, CA 94305, USA.

Science Advances
|September 24, 2025
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Summary
This summary is machine-generated.

This study introduces a novel microneedle device for faster dermal interstitial fluid (ISF) collection. The device significantly improves ISF sampling efficiency and reduces blood contamination for improved skin diagnostics.

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Area of Science:

  • Biomedical Engineering
  • Dermatology
  • Analytical Chemistry

Background:

  • Dermal interstitial fluid (ISF) presents a viable alternative to blood sampling for diagnostics.
  • Current ISF sampling methods face challenges like long collection times, high failure rates, and variable sample volumes.

Purpose of the Study:

  • To develop and validate a novel microneedle device for rapid and efficient ISF collection.
  • To investigate factors influencing ISF collection and establish criteria for sample quality.

Main Methods:

  • Design of a microneedle device engineered to optimize the spatial pressure gradient for ISF flow.
  • In-human testing to evaluate collection speed, volume, failure rates, and blood contamination.
  • Analysis of penetration depth, collection time, pressure, and age effects on ISF yield, applying Darcy's law.

Main Results:

  • The novel microneedle device achieved significantly faster ISF collection, averaging 15.5 mg in 5 minutes.
  • Near-zero failure rate and minimal blood contamination (<1%) were observed.
  • Darcy's law effectively explained the influence of key parameters on ISF collection dynamics.

Conclusions:

  • The developed microneedle device offers a substantial improvement over existing technologies for ISF sampling.
  • The findings provide a foundation for more robust ISF diagnostic studies and improved skin diagnostics.
  • A data-driven criterion for acceptable blood contamination in ISF samples was proposed.