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Related Concept Videos

Patch Clamp01:18

Patch Clamp

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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
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A Microfluidic-based Hydrodynamic Trap for Single Particles
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Acoustically powered micro-clampbot for single-particle transportation.

Zhikun Miao1, Tao Feng1, An Ren2

  • 1Center for X-Mechanics, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.

Science Advances
|September 24, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces an acoustically powered micro-clampbot for precise microobject manipulation. This novel microrobot achieves independent clamping and locomotion control using distinct acoustic frequencies.

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Area of Science:

  • Robotics
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Acoustic microrobots are useful for microobject manipulation.
  • Solely acoustically powered microrobots face challenges in synergistic handling and movement, often requiring auxiliary actuation.
  • Existing systems may need magnetic control for assistance in complex tasks.

Purpose of the Study:

  • To develop an acoustically powered micro-clampbot for independent microobject clamping and locomotion.
  • To enable precise control over micro-manipulation tasks using distinct acoustic frequencies.
  • To demonstrate the capability of solely acoustically powered microrobots in challenging microscale operations.

Main Methods:

  • Developed a micro-clampbot with claws actuated by acoustically induced secondary Bjerknes forces for clamping.
  • Integrated flagella that oscillate under acoustic input for locomotion.
  • Utilized distinct acoustic frequencies to govern independent control of clamping and movement.
  • Tested navigation through narrow channels and selective particle retrieval from clusters.

Main Results:

  • The micro-clampbot successfully clamped and transported microobjects, including live cells, without damage.
  • Independent control of clamping and locomotion was achieved using different acoustic frequencies.
  • The robot navigated narrow channels with constrictions approximately 2.1 times its width.
  • Demonstrated selective particle picking from a cluster.

Conclusions:

  • The developed acoustically powered micro-clampbot offers a versatile solution for microobject transportation.
  • This system overcomes limitations of solely acoustically powered microrobots by enabling synergistic handling and movement.
  • The technology shows significant potential for advanced clinical therapies and microscale operations.