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Updated: Jan 17, 2026

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain
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Sound offset responses become highly informative in the auditory cortex.

Charly Lamothe1, Sophie Bagur1,2, Etienne Gosselin1

  • 1Institut Pasteur, AP-HP, INSERM, CNRS, Fondation Pour l'Audition, Institut de l'Audition, IHU reConnect, Université Paris Cité, Paris, France.

The Journal of Physiology
|September 24, 2025
PubMed
Summary
This summary is machine-generated.

Auditory offset responses are common throughout the brain. Cortical neurons encode sound offset information with greater accuracy, suggesting enhanced short-term memory computations in the auditory cortex.

Keywords:
auditory pathwaysoffset responsespopulation decodingtwo‐photon imaging

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Area of Science:

  • Neuroscience
  • Auditory System Processing
  • Sensory Neuroscience

Background:

  • The auditory system exhibits widespread offset responses following sound termination.
  • The precise origin and processing of these offset responses across auditory stages remain unclear.

Purpose of the Study:

  • To investigate the presence and characteristics of auditory offset responses in the central auditory system.
  • To determine if offset responses are computed centrally or recomputed at each processing stage.
  • To compare the information content of offset responses between cortical and subcortical auditory areas.

Main Methods:

  • Analysis of large-scale neural response datasets from the cochlear nucleus, inferior colliculus, medial geniculate nucleus, and auditory cortex of awake mice.
  • Utilized population activity decoders to assess neural encoding accuracy of sound offset information.

Main Results:

  • Significant offset responses were observed in all analyzed brain regions, often co-occurring with onset and sustained responses.
  • Neural representations of sound offset showed a three-fold increase in encoding accuracy in the auditory cortex compared to subcortical areas.
  • Cortical offset responses encode more precise short-term memory of elapsed sounds than subcortical responses.

Conclusions:

  • Auditory offset responses are a ubiquitous feature across the central auditory system.
  • The auditory cortex exhibits enhanced computational capabilities for processing sound offset information, likely involving specific neural computations.
  • Cortical offset responses contribute richer information about elapsed sounds, suggesting a role in short-term auditory memory.