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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

Comparative evaluation of coagulation profiles across different stages of chronic kidney disease: A cross-sectional

Emelina Stambolliu1, Panagiota Giannou1, Aikaterini Damianaki1

  • 1Nephrology Department, Hippokration General Hospital, Athens, Greece.

Thrombosis Research
|September 24, 2025
PubMed

Insights

Chronic kidney disease (CKD) progression alters coagulation, increasing thrombosis risk even in early stages. Peritoneal dialysis patients show a more hypercoagulable state than hemodialysis patients.

Area of Science:

  • Nephrology
  • Hematology
  • Clinical Chemistry

Background:

  • Patients with chronic kidney disease (CKD), particularly end-stage renal disease (ESRD), face elevated risks of both bleeding and thrombosis.
  • Understanding coagulation abnormalities in CKD is crucial for managing patient outcomes.

Purpose of the Study:

  • To evaluate hemostasis parameters in patients with varying stages of CKD.
  • To identify differences in coagulation processes between non-dialysis CKD, hemodialysis (HD), and peritoneal dialysis (PD) patients.

Main Methods:

  • Cross-sectional study involving 148 patients across CKD stages 2-5, HD, and PD.
  • Standard coagulation tests, thromboelastography (TEG), and platelet function analysis (PFA) were performed.

Main Results:

  • Coagulation parameters (D-Dimers, FVIII, fibrinogen, vWF, aPTT) and TEG values progressively worsened with advancing CKD stages (p < 0.05).
  • Peritoneal dialysis patients exhibited a more hypercoagulable state compared to hemodialysis patients, evidenced by differences in FVIII, vWF, PFA, and TEG.
  • Estimated glomerular filtration rate (eGFR) independently predicted most coagulation and TEG parameters.

Conclusions:

  • CKD progression is associated with a prothrombotic profile, detectable even in early stages.
  • Significant differences in coagulation exist between HD and PD patients, with PD patients showing increased hypercoagulability.
  • These findings highlight the complex hemostatic alterations in CKD and dialysis modalities.
Abstract

Keywords:
Chronic kidney diseaseCoagulationHemostasisPFAThromboelastographyThrombosis

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