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Updated: Jan 17, 2026
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
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Oncolytic virotherapy: Sparking durable anti-tumor immunity through microenvironment modulation
Christoph F Kollmann1, Nadine van Montfoort2, Pierre Cordelier3
1Department of Biomedicine, Aarhus University, Denmark.
Seminars in Immunology
|September 24, 2025
Summary
Oncolytic virotherapy (OVT) uses viruses to destroy cancer cells and activate the immune system. This approach reshapes the tumor microenvironment, enhancing immunotherapy effectiveness for better cancer treatment outcomes.
Area of Science:
- Oncology
- Immunology
- Virology
Background:
- Oncolytic virotherapy (OVT) is an emerging cancer treatment strategy.
- OVT leverages viruses for selective tumor cell destruction.
- OVT also modulates the tumor microenvironment (TME) to stimulate anti-tumor immunity.
Purpose of the Study:
- To review the mechanisms of OVT in reshaping the TME.
- To explore OVT's synergy with other immunotherapies.
- To highlight clinical evidence of OVT's efficacy.
Main Methods:
- Review of scientific literature on OVT and TME interactions.
- Analysis of OVT's impact on tumor cell death and immune cell infiltration.
- Examination of clinical trial data for OVT in cancer patients.
Main Results:
- OVT induces immunogenic cell death, releasing tumor antigens.
- OVT alters TME composition and physical structure.
- OVT converts 'cold' tumors to 'hot' tumors, enhancing immune response.
- Combination of OVT with immune checkpoint inhibitors shows promise.
Conclusions:
- OVT is a potent immunotherapy adjunct that enhances TME immunogenicity.
- OVT offers new strategies to overcome cancer treatment resistance.
- OVT shows potential for achieving durable systemic anti-tumor immunity.
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