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Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
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New frontier for epilepsy treatment through targeting cellular senescence

Stephen Temitayo Bello1, Md Rajdoula Rafe2, Fengwen Huang1

  • 1Department of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong Special Administrative Region; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, New Territories, Hong Kong, China.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|September 24, 2025
PubMed

Insights

Cellular senescence, a process halting cell growth, is linked to epilepsy. Understanding senescence-associated secretory phenotype (SASP) and senolytics may offer new epilepsy treatment strategies.

Area of Science:

  • Neurology
  • Cell Biology
  • Gerontology

Background:

  • Epilepsy affects 1-2% of the global population, necessitating improved therapeutic strategies.
  • Cellular senescence, a state of irreversible growth arrest, is implicated in various neurological disorders, including epilepsy.
  • A deeper understanding of cellular senescence's role in epilepsy is crucial for developing effective treatments.

Purpose of the Study:

  • To review the mechanisms driving cellular senescence and its associated secretory phenotype (SASP).
  • To explore the link between cellular senescence and epilepsy development and progression.
  • To discuss senolytics and senomorphics as potential therapeutic interventions for epilepsy.

Main Methods:

  • Literature review of cellular senescence mechanisms and pathways.
  • Analysis of the senescence-associated secretory phenotype (SASP) and its inflammatory effects.
  • Examination of cell types, including brain cells, undergoing senescence in the context of epilepsy.

Main Results:

  • Cellular senescence and SASP contribute to inflammation and tissue dysfunction relevant to epilepsy.
  • Specific cellular senescence mechanisms and pathways are associated with epilepsy development.
  • Potential biomarkers linking cellular senescence and epilepsy have been identified.

Conclusions:

  • Cellular senescence is a significant factor in epilepsy development and progression.
  • Targeting cellular senescence pathways, including SASP, offers novel therapeutic avenues for epilepsy.
  • Senolytics and senomorphics show promise for future epilepsy treatment strategies.
Keywords:
Cellular senescenceEpilepsySeizureSenolyticsSenomorphics

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