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Randomised trials in child and adolescent health in low- and middle-income countries in 2024-2025

Trevor Duke1,2

  • 1Department of Paediatrics and Intensive Care Unit, Royal Children's Hospital, The University of Melbourne, Melbourne, Victoria, Australia trevor.duke@rch.org.au.

Archives of Disease in Childhood
|September 24, 2025
PubMed

Insights

Hundreds of randomized controlled trials in low- and middle-income countries address child health annually. This year

Area of Science:

  • Global child health research
  • Paediatric clinical trials
  • Adolescent health studies

Background:

  • Significant research efforts are dedicated to child and adolescent health in low- and middle-income countries.
  • Annual compilations track the progress and scope of clinical paediatrics research globally.

Purpose of the Study:

  • To summarize the landscape of randomized controlled trials in child health conducted in low- and middle-income countries.
  • To highlight the diversity of research topics and their potential impact on practice and policy.

Main Methods:

  • Inclusion of 600 randomized controlled trial publications in an annual compilation.
  • Analysis of studies addressing clinical paediatrics and child and adolescent health issues.
  • Geographical representation from all global regions.

Main Results:

  • Hundreds of randomized controlled trials are conducted annually in low- and middle-income countries.
  • The 600 included publications cover a wide range of child and adolescent health topics.
  • Studies originate from diverse geographical regions worldwide.

Conclusions:

  • The body of evidence from randomized controlled trials in low- and middle-income countries is substantial and growing.
  • These trials address critical issues in child and adolescent health.
  • Findings have the potential to inform and change clinical practice and health policies globally.

Keywords:
child healthneonatologypaediatrics

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