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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Fibromyalgia and hand diseases: A case-control study.

Eli Magen1, Suhail Aamar2, Viktor Feldman3

  • 1Leumit Health Services, R&D Unit, Tel Aviv-Yafo, Israel; Medicine A Department, Assuta Ashdod University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.

Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists
|September 24, 2025
PubMed
Summary
This summary is machine-generated.

Fibromyalgia significantly increases the risk of various hand diseases, including carpal tunnel syndrome and osteoarthritis. Patients with fibromyalgia experience higher rates of hand-related surgeries and healthcare utilization, necessitating early screening and management.

Keywords:
Carpal tunnel syndromeCase-control studyFibromyalgiaHand diseasesHealthcare utilization

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Area of Science:

  • Rheumatology
  • Orthopedics
  • Epidemiology

Background:

  • Fibromyalgia is a chronic condition causing widespread pain and fatigue.
  • Its association with specific hand disorders impacting daily function remains unclear.

Purpose of the Study:

  • To investigate the prevalence of hand diseases in fibromyalgia patients.
  • To assess healthcare utilization and surgical interventions for hand conditions in this population.

Main Methods:

  • A retrospective, population-based, matched case-control study using electronic health records.
  • 9,232 fibromyalgia patients were matched 5:1 with 46,160 controls.
  • Hand diseases diagnosed via ICD-9 codes; surgical rates and healthcare utilization analyzed.

Main Results:

  • Fibromyalgia is linked to significantly higher odds of carpal tunnel syndrome (OR 2.98), trigger finger (OR 1.77), De Quervain's tenosynovitis (OR 1.96), tendinitis (OR 2.16), and hand osteoarthritis (OR 2.99).
  • Fibromyalgia patients showed increased healthcare utilization and surgical rates for carpal tunnel release (OR 2.57) and trigger finger repair (OR 2.98).

Conclusions:

  • Fibromyalgia is associated with a higher prevalence of hand diseases and surgical interventions.
  • Early screening and multidisciplinary management of hand conditions are recommended for fibromyalgia patients to prevent disability.