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Optic Disc and Retinal Structural Changes in Takayasu Arteritis: Implications for Normotensive Glaucoma.

Esra Bulut Kızılay1, Fehim Esen2, Muhammed Emin Kızılay1

  • 1Ophthalmology, Erzurum Research Hospital, Erzurum, Turkey.

Ocular Immunology and Inflammation
|September 24, 2025
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Summary

Takayasu arteritis patients show optic nerve changes, including thinner lamina cribrosa, even with normal eye pressure. These early structural alterations may indicate neurodegeneration, not glaucoma.

Keywords:
Normotensive glaucomaTakayasu arteritisocular blood flow

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Neuroscience

Background:

  • Takayasu arteritis is a large-vessel vasculitis affecting major arteries.
  • Ocular hypoperfusion from Takayasu arteritis may damage the optic nerve.
  • This study explores optic nerve changes similar to normotensive glaucoma in Takayasu arteritis.

Purpose of the Study:

  • To investigate optic nerve head structural changes in patients with Takayasu arteritis.
  • To determine if Takayasu arteritis is associated with early signs of normotensive glaucoma.
  • To identify potential biomarkers for neurodegenerative effects in Takayasu arteritis.

Main Methods:

  • 62 Takayasu arteritis patients and 51 healthy controls were included.
  • Comprehensive ophthalmological examinations were performed.
  • Measurements included RNFL, ganglion cell layer, BMO-MRW, choroidal thickness, lamina cribrosa, and visual fields.

Main Results:

  • Lamina cribrosa was significantly thinner in Takayasu arteritis patients (p < 0.001).
  • Patients showed lower mean deviation (p = 0.03) and higher pattern standard deviation (p = 0.01) on visual fields.
  • No significant differences in RNFL or ganglion cell layer thickness were found.

Conclusions:

  • Takayasu arteritis patients exhibit optic nerve changes, notably thinner lamina cribrosa, under normotensive IOP.
  • These findings suggest subclinical structural alterations, not definitive glaucomatous damage.
  • Thinner lamina cribrosa may be a biomarker for neurodegenerative effects in Takayasu arteritis.