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Updated: Jan 17, 2026
Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
High prevalence of renal amyloidosis in cats in an overcrowded colony
Ayami Yutsudo1, Natsume Kurahara1, Shigeki Yamano2
1Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Abstract:
Multiple cats in an overcrowded colony died of acute kidney injury with renal amyloidosis. To investigate the etiology of these deaths, we performed histological analysis of the kidneys of 27 colony cats and 29 noncolony cats (8 with acute kidney injury, 9 with chronic kidney disease, and 12 nonazotemic). Congo red-positive amyloid deposition was observed prominently in the glomeruli and cortical and medullary interstitium and was identified as AA amyloid using permanence. The prevalence and severity of renal amyloidosis were significantly higher in colony cats than in noncolony cats. Feline immunodeficiency virus showed no association with feline leukemia virus infection. Based on our results, adverse environmental conditions may accelerate the incidence of feline renal amyloidosis.
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