Related Experiment Video For Atherosclerotic plaque
Updated: Jan 17, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Cytochrome C-Dependent Processes of Damage of Atherosclerotic Plaque Membranes Regulated by Anionic Phospholipids
G O Stepanov1, V V Volkov2, S P Konukhova2
1Department of General and Medical Biophysics, Medical Biological Faculty, Pirogov Russian National Research Medical University (Pirogov University), Ministry of Health of the Russian Federation, Moscow, Russia. stepanov_go@rsmu.ru.
Abstract:
We have shown that changes in the phospholipid and fatty acid composition of atherosclerotic plaques in the carotid arteries of patients who underwent carotid endarterectomy in combination with coronary artery bypass surgery are linked with the development of the pathological process and highlight the importance of cytochrome C-mediated induction of oxidation of membrane phospholipids. An increase of the steady-state equilibrium constant of cytochrome C with atherosclerotic membranes to 10-5 M and simultaneously a more than three-fold enhancement of LPO process are demonstrated.
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