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The relation between breast artery calcification and subclinical left ventricular systolic dysfunction.

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Breast artery calcification (BAC) is linked to subclinical left ventricular systolic dysfunction (LVSD). Detecting BAC on mammograms may identify patients at risk for heart failure.

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Area of Science:

  • Cardiology
  • Radiology
  • Echocardiography

Background:

  • Cardiovascular diseases (CVD) are leading causes of death.
  • Breast artery calcification (BAC) is associated with CVD.
  • Subclinical left ventricular systolic dysfunction (LVSD) is an early indicator of cardiac issues.

Purpose of the Study:

  • To investigate the relationship between BAC and subclinical LVSD using strain echocardiography.
  • To determine if BAC is an independent predictor of LVSD.

Main Methods:

  • Prospective study including 94 patients with BAC and 100 age-matched controls without BAC.
  • Strain echocardiography was used to assess global longitudinal strain (GLS) and diastolic function.
  • Patients were categorized by BAC presence and severity (grades), and LVSD status.

Main Results:

  • Patients with BAC showed significantly lower GLS compared to controls (p < 0.0001).
  • GLS decreased with increasing BAC grades (p < 0.0001).
  • BAC grade 3, elevated E/e', and NLr were independent risk factors for LVSD.

Conclusions:

  • BAC is associated with subclinical LVSD.
  • BAC grade 3 is an independent predictor of LVSD.
  • Mammographic detection of BAC may aid in identifying individuals at risk for heart failure.