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Applications of New Generation Sequencing (NGS) in Ocular Oncology

Mizuki Tagami1, Shigeru Honda

  • 1Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

International Ophthalmology Clinics
|September 25, 2025
PubMed

Insights

Next-generation sequencing (NGS) transforms ocular oncology by revealing cancer genomics. This technology aids in early diagnosis, risk assessment, and personalized treatments for eye cancers.

Area of Science:

  • Ophthalmology
  • Genomics
  • Oncology

Background:

  • Next-generation sequencing (NGS) provides deep insights into cancer genomics.
  • Ocular cancers present unique genomic landscapes.
  • Understanding these landscapes is crucial for effective treatment.

Purpose of the Study:

  • To review the role and impact of NGS in ocular oncology.
  • To highlight NGS applications in various eye tumors.
  • To discuss future directions for NGS in clinical practice.

Main Methods:

  • Literature review of NGS applications in ocular oncology.
  • Analysis of studies focusing on uveal melanoma, retinoblastoma, and other ocular tumors.
  • Discussion of challenges and future prospects.

Main Results:

  • NGS enhances understanding of genetic alterations in ocular cancers.
  • Identifies novel biomarkers for diagnosis and prognosis.
  • Facilitates personalized therapeutic strategies.

Conclusions:

  • NGS is revolutionizing ocular oncology.
  • Integration into clinical practice promises improved diagnosis, risk stratification, and treatment.
  • Continued technological evolution will further advance eye cancer care.
Keywords:
IgG4-related ophthalmic disease (IgG4-ROD)RNA-seqSTINGimmunohistochemistrymachine learningorbital MALT lymphomaprincipal component analysis

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