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Updated: Jan 17, 2026

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
Published on: January 10, 2025
[Chronic cough: recommendations for primary care physicians]
Corentin Van Ruymbeke1, Stéphane Talbit1, Caroline Rayroux2
1Service de médecine de premier recours, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
Chronic cough, defined as a cough lasting longer than 8 weeks, is a common complaint in primary care settings. It is now recognized as a distinct clinical entity, often associated with cough reflex hypersensitivity. Chronic cough has an impact on quality of life and assessing it remains a key component in tailoring management. The initial workup includes a chest X-ray, spirometry, and complete blood count. Current guidelines emphasize the importance of a thorough clinical assessment to identify and address modifiable causes and limit empirical treatments, as previously recommended. The etiological spectrum has expanded to include conditions such as obesity and sleep apnea, underlining the need for a multidisciplinary approach. In the absence of a clear etiology or treatment response, referral to a specialist is recommended.
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Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...

