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Sensitive, Low-Cost, Early Detection of Periodontal Disease Using Surface-Enhanced Raman Spectroscopy with
Yumeng Jiang1, Ryosuke Yanagida2, Mitsuko Saito2,3
1Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.
Analytical Chemistry
|September 25, 2025
Summary
A new, low-cost method using surface-enhanced Raman spectroscopy on a periopaper strip offers sensitive, early detection of periodontal disease. This user-friendly approach analyzes gingival fluid biomarkers in situ, aiding timely intervention for oral and systemic health.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Periodontology
Background:
- Periodontal disease is a prevalent inflammatory condition linked to systemic diseases.
- Current diagnostic methods have limitations including invasiveness, cost, and low sensitivity.
- Early detection is crucial for effective management and prevention of complications.
Purpose of the Study:
- To develop a sensitive, low-cost, and user-friendly method for early periodontal disease detection.
- To overcome the limitations of existing diagnostic tools.
- To enable in situ analysis of gingival crevicular fluid biomarkers.
Main Methods:
- Utilized surface-enhanced Raman spectroscopy (SERS) with a silver-nanomesh-coated periopaper strip.
- Developed a flexible substrate for direct in situ analysis of gingival crevicular fluid.
- Validated the system in a clinical study involving 43 teeth from 34 participants.
Main Results:
- The SERS-based platform demonstrated high sensitivity for early-stage periodontal disease detection.
- The system reliably differentiated disease severity, including advanced cases (up to 10 mm pocket depth).
- Achieved repeatable measurements and demonstrated greater environmental stability compared to saliva assays.
Conclusions:
- The developed method is a sensitive, affordable, and robust tool for early periodontal disease diagnosis.
- Its user-friendliness makes it suitable for primary care and resource-limited settings.
- The platform's extensibility offers potential for diagnosing various oral and systemic diseases.
