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Fosaprepitant Dimeglumine Alleviates Dengue Virus Infection and Virus-Induced Inflammatory Responses

Xueyi Deng1, Ningze Zheng1, Shurui Liu1

  • 1Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

ACS Infectious Diseases
|September 25, 2025
PubMed
Summary

Fosaprepitant dimeglumine, an anti-nausea drug, effectively inhibits dengue virus (DENV) replication and reduces severe dengue-associated inflammation. This finding suggests its potential for repurposing as a dengue antiviral therapy.

Keywords:
antiviral therapydenguefosaprepitant dimeglumineneurokinin-1 receptor antagonist

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