Related Experiment Video

Updated: Jan 17, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.4K

Prevalence of Allergic Bronchopulmonary Aspergillosis in Bronchial Asthma Patients: A Retrospective Observational

Arnab Swain1

  • 1Pulmonary Medicine, Postgraduate Institute of Medical Education and Research and Capital Hospital, Bhubaneswar, IND.

Cureus
|September 25, 2025
PubMed

Insights

Allergic bronchopulmonary aspergillosis (ABPA) affects 14% of asthma patients, often presenting with dyspnea. Early screening using chest imaging and IgE levels is vital for timely treatment.

Area of Science:

  • Pulmonology
  • Allergy and Immunology
  • Medical Diagnostics

Background:

  • Asthma is a chronic airway inflammation exacerbated by fungal allergens like Aspergillus fumigatus.
  • Allergic bronchopulmonary aspergillosis (ABPA) is a severe hypersensitivity reaction in some asthma patients.
  • Understanding ABPA prevalence and characteristics in asthma is crucial for management.

Purpose of the Study:

  • To determine the prevalence of ABPA in bronchial asthma patients.
  • To describe the clinical, radiological, and immunological profiles of asthma patients with ABPA.
  • To evaluate diagnostic utility of imaging and serological markers.

Main Methods:

  • Retrospective observational study over 18 months at a tertiary care hospital.
  • Reviewed data from 100 bronchial asthma patients undergoing pulmonary function testing (PFT).
  • ABPA diagnosis based on serum IgE, specific IgE to A. fumigatus, chest imaging (X-ray, HRCT), and eosinophilia.

Main Results:

  • ABPA diagnosed in 14% of asthma patients; common in 21-30 year olds (69% male).
  • Dyspnea (64%) was the most frequent symptom.
  • ABPA observed across asthma severity spectrum (mild 21%, moderate 7%, severe 11%); chest infiltrates showed high sensitivity but low specificity.

Conclusions:

  • ABPA is present in a significant proportion of asthma patients, necessitating early identification.
  • Chest imaging and serum IgE levels are valuable screening tools for ABPA in asthma.
  • Prompt diagnosis of ABPA impacts treatment strategies and patient outcomes.
Keywords:
abpaaspergillus fumigatusbronchial asthmahrctigepft

More Related Videos

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

23.3K
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

11.0K

Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.3K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.1K