Epigenetic modifications in developmental coordination disorder: association between DNA methylation and motor...

Area of Science:

• Neuroscience
• Genetics
• Developmental Biology

Background:

• Developmental Coordination Disorder (DCD) is a prevalent neurodevelopmental condition impacting motor coordination.
• The underlying biological mechanisms of DCD are not fully understood.
• Investigating epigenetic factors like DNA methylation is crucial for understanding DCD pathogenesis.

Purpose of the Study:

• To explore the role of DNA methylation in the development of DCD.
• To identify specific DNA methylation patterns associated with motor coordination deficits.

Main Methods:

• Genome-wide DNA methylation analysis was performed on peripheral blood samples from children with and without DCD.
• Differentially methylated probes (DMPs) and regions (DMRs) were identified using computational algorithms (Bumphunter, ProbeLasso).
• Targeted sequencing (MethylTarget™) was used for validating key DMPs.

Main Results:

• A significant number of DMPs (416) and DMRs (48 and 22) were identified between DCD and control groups.
• Specific DMPs in genes such as *FAM45A*, *FAM184A*, *SEZ6*, and *GPD2* showed significant associations with motor function scores.
• Methylation levels at cg18187326 (*FAM45A*) and cg11968956 (*FAM184A*) correlated with total and gross motor scores.

Conclusions:

• Specific DNA methylation alterations are associated with early motor development and may contribute to DCD.
• Identified DNA methylation markers show potential as novel biomarkers for early DCD diagnosis.
• These findings could pave the way for targeted interventions in children with DCD.