Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Area of Science:

• Neuroscience
• Biochemistry
• Nanotechnology

Background:

• Brain metabolism is uniquely regulated and alterations are key drivers in brain diseases.
• Dysregulated metabolism disrupts cell interactions, creating a pro-disease microenvironment.
• Current therapeutic strategies targeting metabolic changes are fundamental for disease intervention.

Purpose of the Study:

• To summarize metabolic network characteristics in brain diseases.
• To explore nanodelivery systems for metabolic regulation in brain diseases.
• To establish a novel therapeutic paradigm for brain diseases using nanodelivery systems.

Main Methods:

• Review of metabolic network characteristics in brain diseases.
• Exploration of smart nanodelivery systems for metabolic regulation.
• Analysis of nanodelivery system combinations for therapeutic potential.

Main Results:

• Metabolic dysregulation involves substance transport, cell signaling, and microenvironment dynamics.
• Smart nanodelivery systems offer precise modulation of metabolic networks.
• Nanodelivery systems show promise in combination therapies for brain diseases.

Conclusions:

• Targeting brain metabolic networks is crucial for disease intervention.
• Smart nanodelivery systems provide a versatile platform for metabolic regulation.
• This review highlights a novel therapeutic paradigm for brain diseases.