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Association between serum GDF-15 and hypertension in the third trimester of pregnancy

Cheng Chen1, Qin Li1, Yanxiang Wang2

  • 1Department of Medical Science, Yangzhou Polytechnic College, Yangzhou, Jiangsu Province, China.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|September 25, 2025
PubMed

Insights

Serum Growth Differentiation Factor 15 (GDF-15) was elevated in pregnant women with hypertensive disorders of pregnancy (HDP). Higher GDF-15 levels correlated with increased blood pressure in these patients.

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Health
  • Biomarkers in Pregnancy

Background:

  • Hypertensive disorders of pregnancy (HDP) pose significant risks to maternal and fetal health.
  • Understanding the underlying pathophysiology of HDP is crucial for improved management.
  • Growth Differentiation Factor 15 (GDF-15) is a cytokine with potential roles in inflammatory and stress responses.

Purpose of the Study:

  • To investigate serum Growth Differentiation Factor 15 (GDF-15) expression in third-trimester pregnant women with HDP.
  • To examine the correlation between serum GDF-15 levels and blood pressure parameters (systolic and diastolic) in women with HDP.

Main Methods:

  • A cross-sectional study design was employed.
  • Participants included 60 third-trimester pregnant women diagnosed with HDP and 50 healthy pregnant controls.
  • Serum GDF-15 levels were quantified, and clinical characteristics were recorded.

Main Results:

  • Serum GDF-15 levels were significantly higher in the HDP group compared to the control group.
  • A positive correlation was observed between serum GDF-15 levels and both systolic and diastolic blood pressure in women with HDP.

Conclusions:

  • Elevated serum GDF-15 may serve as a potential biomarker in hypertensive disorders of pregnancy.
  • GDF-15 levels appear to be associated with the severity of HDP, particularly concerning blood pressure elevation.
Abstract

Keywords:
Growth differentiation factor 15adverse maternal outcomesdiastolic blood pressurehypertensive disorders of pregnancysystolic blood pressurethird-trimester pregnant

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