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Therapeutic Plasmapheresis in a Tertiary Pediatric Intensive Care Unit: A 10-Year Single-Center Experience

Abdullah Akkuş1, Ahmet Osman Kılıç1, Nefise Betül Ercan2

  • 1Department of Pediatrics, Faculty of Medicine, Necmettin Erbakan University, Konya, Türkiye.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|September 25, 2025
PubMed

Insights

Therapeutic plasmapheresis (TP) is a vital supportive therapy for critically ill children in the pediatric intensive care unit (PICU). Early TP initiation may be life-saving for conditions like septic shock and MIS-C.

Area of Science:

  • Pediatric Critical Care Medicine
  • Extracorporeal Therapies

Background:

  • Therapeutic plasmapheresis (TP) is an extracorporeal treatment for diverse diseases.
  • Its application in pediatric intensive care units (PICUs) warrants further investigation.

Purpose of the Study:

  • To evaluate the utilization and outcomes of therapeutic plasmapheresis in a pediatric intensive care unit.
  • To identify common indications, complications, and mortality rates associated with TP in critically ill children.

Main Methods:

  • Retrospective study of pediatric patients receiving TP between 2013 and 2023.
  • Data collected from medical records of patients admitted to the PICU.

Main Results:

  • 72 children received TP; common indications were septic shock and multisystem inflammatory syndrome in children (MIS-C).
  • Median TP sessions were 2, median PRISM III score was 14.5.
  • Mortality rate was 44.4%, with complications including thrombosis in 5.6%.

Conclusions:

  • Therapeutic plasmapheresis serves as crucial supportive therapy for critically ill pediatric patients.
  • Early initiation of TP, guided by appropriate indications, may improve survival rates.
Abstract

Keywords:
childintensive careplasmapheresissepsis

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