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  11. Case Report: Mri Diagnosis Of Wilson's Disease In A 3-year-old Dalmatian

Case Report: MRI Diagnosis of Wilson's Disease in a 3-Year-Old Dalmatian

Natalie Durant1, Matthew Paek2, Wilfried Mai1

  • 1Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
|September 25, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

This study details a Dalmatian diagnosed with Wilson's disease, a copper storage disorder. Brain MRI revealed characteristic changes, which improved with chelation therapy, marking the first such description in dogs.

Area of Science:

  • Veterinary Neurology
  • Canine Hepatology
  • Comparative Neuroimaging

Background:

  • Wilson's disease, a genetic disorder causing copper accumulation, is rare in dogs.
  • Neurological signs and liver dysfunction can indicate metabolic disease in canines.

Purpose of the Study:

  • To describe the brain Magnetic Resonance Imaging (MRI) findings in a dog with Wilson's disease.
  • To correlate MRI findings with clinical signs and liver pathology.

Main Methods:

  • A 3-year-old Dalmatian with neurological signs and hepatopathy underwent MRI.
  • A hepatic biopsy was performed for copper quantification.
  • The dog received chelation therapy.

Main Results:

  • MRI revealed specific brain lesions (T2W/T2-FLAIR hyperintensities and T1-hyperintensities) in key areas.
Keywords:
brain metabolic disorders | copper hepatopathy | dog

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  • Hepatic biopsy confirmed severe copper-associated hepatitis (3052 µg/g dry weight).
  • Clinical signs and MRI abnormalities improved after chelation therapy.

    • Conclusions:

    • The findings support a diagnosis of copper storage hepatopathy, consistent with Wilson's disease in this dog.
    • This case represents the first documented brain MRI findings associated with Wilson's disease in a canine patient.