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Tofacitinib successful treatment of idiopathic twenty-nail dystrophy: a case report
Wenjun Zhao1, Shijun Shan1, Dongmei Liu1
1Department of Dermatology, Jinhua Fifth Hospital, Jinhua, Zhejiang, China.
Purpose:
Twenty-nail dystrophy (TND) is a chronic nail disorder affecting all or some nails and posing a significant therapeutic challenge for dermatologists. Janus kinase (JAK) inhibitors have recently emerged as a promising treatment modality for refractory nail diseases.
Results:
We report a case of a patient with idiopathic TND for 12 years duration, and successfully treated with oral tofacitinib, which offered a potential new therapeutic choice for this challenging entity. Some successful cases of treating inflammatory nail diseases with Janus kinase (JAK) inhibitors were reviewed.
Conclusion:
Janus kinase (JAK) inhibitors may be a promising therapeutic option for patients with twenty-nail dystrophy.
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