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How does high-refractive error affect quantitative pupillometry values?

Dilara Özkoyuncu Kocabas1, Fuat Yavrum2

  • 1Department of Ophthalmology, TOBB Economics and Technology University Faculty of Medicine, Ankara, Turkey.

Indian Journal of Ophthalmology
|September 25, 2025
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Summary

High hyperopic eyes show distinct static pupil responses compared to high myopic and emmetropic eyes. Pupil dilation speed, however, remains unaffected by high refractive errors.

Keywords:
Dynamic pupillometryhigh hyperopiahigh myopiapupil dilation speedstatic pupillometry

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Area of Science:

  • Ophthalmology
  • Physiological Optics
  • Refractive Error Research

Background:

  • Pupil size is influenced by refractive error.
  • Understanding pupil responses can aid in differentiating refractive conditions.
  • High refractive errors, including myopia and hyperopia, may alter ocular characteristics.

Purpose of the Study:

  • To investigate static and dynamic pupil responses.
  • To differentiate eyes with high refractive errors from emmetropic controls.
  • To assess pupil diameter and dilation speed in high myopia and high hyperopia.

Main Methods:

  • Evaluated 36 high myopic, 26 high hyperopic, and 38 control participants.
  • Measured cycloplegic spherical equivalent refraction (SER) and axial length (AL).
  • Assessed static pupillometry across scotopic, mesopic, and photopic conditions and dynamic pupillometry for dilation speed.

Main Results:

  • High hyperopic eyes had smaller scotopic and mesopic pupil diameters than high myopic and control eyes.
  • Photopic pupil diameter was significantly lower in the high hyperopic group.
  • No significant differences in static pupillometry between high myopia and controls; dilation speed was not significantly different across groups.

Conclusions:

  • Static pupil responses differ notably in high hyperopic eyes compared to high myopic and emmetropic eyes.
  • High refractive errors do not significantly impact the speed of pupil dilation.
  • Pupil response analysis may offer insights into refractive error characteristics.