Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microbial characterization of oral microbiome in patients with open-angle glaucoma.

Scientific reports·2026
Same author

Evaluation of corneal infections using a smartphone macro lens for synchronous telemedicine.

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society·2026
Same author

Posterior Segment Risk Factors for Penetrating Keratoplasty Failure.

American journal of ophthalmology·2026
Same author

Global Consensus on Keratoconus and Ectatic Diseases-Edition 2.

Cornea·2026
Same author

The Critical Role of Oxygen Supplementation in Epithelium-On Corneal Cross-Linking: A Narrative Review.

Advances in therapy·2026
Same author

High Burden of Constipation Among Autistic Youth: A Nationwide Query Powered by PCORnet.

The American journal of gastroenterology·2026

Related Experiment Video

Updated: Jul 15, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.4K

Rates and Risk Factors for Failure After Corneal Collagen Crosslinking for Keratoconus: An IRIS Registry Analysis.

Bryce Hwang1,2, Binod Acharya2,3, Maurizio Tomaiuolo3

  • 1Cornea Service, Wills Eye Hospital, Philadelphia, PA.

Cornea
|September 25, 2025
PubMed
Summary

Corneal collagen crosslinking (CXL) failure occurred in about 1.3% of keratoconus (KCN) patients within 3 years. Younger patients under 18 faced the highest risk of CXL failure, necessitating repeat treatment or transplantation.

Keywords:
corneal collagen crosslinkingkeratoconuskeratoplasty

More Related Videos

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

8.2K
Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

1.8K

Related Experiment Videos

Last Updated: Jul 15, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.4K
Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

8.2K
Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

1.8K

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Regenerative Medicine

Background:

  • Keratoconus (KCN) is a progressive corneal ectasia.
  • Corneal collagen crosslinking (CXL) is a standard treatment for progressive KCN.
  • Understanding CXL failure rates and risk factors is crucial for patient management.

Purpose of the Study:

  • To determine the incidence and identify risk factors for CXL failure in patients with KCN.
  • To analyze outcomes using a large national clinical registry.

Main Methods:

  • Retrospective analysis of 11,731 eyes from 8,568 patients with KCN treated with CXL (2016-2022).
  • Inclusion criteria: treatment-naïve KCN, CXL procedure, and at least 6-month follow-up.
  • Primary outcome: Kaplan-Meier estimate of CXL failure (repeat CXL, PK, or DALK) within 3 years.
  • Statistical analysis: Mixed-effects Cox proportional hazards model to assess risk factors.

Main Results:

  • CXL failure occurred in 1.3% of eyes (148/11,731) within 3 years.
  • Estimated 3-year and 5-year CXL failure rates were 2.0% and 4.5%, respectively.
  • Risk factors for CXL failure included age <18 years (HR: 2.02) and unilateral CXL (HR: 1.54).

Conclusions:

  • Approximately 1 in 50 eyes with KCN undergoing CXL experienced failure within 3 years.
  • Younger patients (<18 years) demonstrated a significantly higher risk of CXL failure.
  • These findings highlight the importance of age as a predictor for CXL outcomes in KCN.