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Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
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New prognostic markers for IgA nephropathy in children
Chiara Casuscelli1, Elisa Longhitano1, Giovanni Conti2
1Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, A.O.U. "G.Martino, " University of Messina, 98125, Messina, Italy.
Pediatric Nephrology (Berlin, Germany)
|September 25, 2025
Summary
IgA nephropathy (IgAN) is a common kidney disease. New biomarkers and prediction tools show promise for identifying children at risk of chronic kidney disease progression, aiding early intervention.
Area of Science:
- Nephrology
- Pediatric Nephrology
- Immunology
Background:
- IgA nephropathy (IgAN) is the leading cause of glomerulonephritis globally, affecting both children and adults.
- Disease progression in IgAN is variable, with a significant percentage of pediatric cases advancing to end-stage renal disease (ESRD).
- Accurate prognostic markers are essential for timely intervention and managing IgAN in children.
Purpose of the Study:
- To review current and emerging prognostic markers for IgA nephropathy in pediatric populations.
- To evaluate the utility of existing prediction tools and novel biomarkers in forecasting disease progression.
- To highlight the need for further research in validating these tools for improved pediatric IgAN management.
Main Methods:
- Review of existing literature on IgA nephropathy prognostic markers.
- Analysis of the performance of the International IgAN Prediction Tool in pediatric cohorts.
- Assessment of emerging biomarkers, including serological and urinary markers.
Main Results:
- The International IgAN Prediction Tool demonstrates high accuracy in predicting chronic kidney disease stage 5 (CKD 5) in children.
- Established markers like proteinuria, eGFR, blood pressure, and the Oxford MEST-C score aid in risk stratification.
- Novel biomarkers such as the IgA/C3 ratio, galactose-deficient IgA1, and urinary cytokines show potential for predicting IgAN progression.
Conclusions:
- Predictive tools and biomarkers are crucial for stratifying risk and guiding treatment in pediatric IgAN.
- Further validation of emerging biomarkers in pediatric populations is necessary.
- Refined predictive models will facilitate targeted therapies and improve long-term renal outcomes for children with IgAN.
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