Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

WWII and the evolution of US federal research funding.

Science (New York, N.Y.)·2026

Same author

In (qualified) defense of the research project grant.

Science (New York, N.Y.)·2026

Same author

TRIPS, pharmaceutical patents, and generic competition in India.

Health affairs scholar·2026

Same author

Using Bayh-Dole Act March-In Rights to Lower US Drug Prices.

JAMA health forum·2024

Same author

Laparoscopic Resection of Para-Aortic Mass at the Aortic Bifurcation: An Atypical Presentation of a Tailgut Cyst.

Cureus·2024

Same author

Self-Trephination in Cranial Excoriation Disorder.

Neurosurgery·2024

Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026

Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026

Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026

Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026

Same journal

Retraction.

Science (New York, N.Y.)·2026

Same journal

Making time.

Science (New York, N.Y.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 1, 2026

Reducing State Anxiety Using Working Memory Maintenance

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

What if NIH had been 40% smaller?

Pierre Azoulay^1,2, Matthew Clancy³, Danielle Li^1,2

¹Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA, USA.

Science (New York, N.Y.)

|September 25, 2025

Summary

This summary is machine-generated.

Reduced National Institutes of Health (NIH) funding significantly impacted drug-linked scientific research. This historical analysis reveals broad consequences across the research landscape.

More Related Videos

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput

Published on: September 22, 2019

Optimized Workflow for Iterative Bleaching Extends Multiplexity Imaging of Highly Autofluorescent Clinical Samples

Optimized Workflow for Iterative Bleaching Extends Multiplexity Imaging of Highly Autofluorescent Clinical Samples

Published on: July 11, 2025

Related Experiment Videos

Last Updated: May 1, 2026

Reducing State Anxiety Using Working Memory Maintenance

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput

Published on: September 22, 2019

Optimized Workflow for Iterative Bleaching Extends Multiplexity Imaging of Highly Autofluorescent Clinical Samples

Optimized Workflow for Iterative Bleaching Extends Multiplexity Imaging of Highly Autofluorescent Clinical Samples

Published on: July 11, 2025

Area of Science:

Biomedical research
Health policy
Drug discovery

Background:

The National Institutes of Health (NIH) is a primary funder of biomedical research in the United States.
Funding levels can influence research direction and productivity.

Purpose of the Study:

To analyze the impact of decreased NIH funding on drug-linked research.
To assess the extent and nature of these impacts.

Main Methods:

Historical analysis of NIH funding trends.
Bibliometric analysis of drug-linked research publications.
Correlation analysis between funding levels and research output.

Main Results:

Significant negative correlations observed between reduced NIH funding periods and the volume of drug-linked research.
Specific therapeutic areas or research types showed disproportionate impacts.
Widespread effects noted across various research institutions and stages of drug development.

Conclusions:

NIH funding levels are a critical determinant of drug-linked research activity.
Policy changes affecting NIH budgets have far-reaching consequences for scientific advancement in pharmaceuticals.
Further investigation into mitigating the effects of funding fluctuations is warranted.