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The Evaluation of Retinal, Choroidal, Scleral, and Optic Disc Parameters in Acromegaly
Onur Furundaoturan1, Cumali Degirmenci2, Özer Sakin2
1Bandirma Onyedi Eylul University Faculty of Medicine, Department of Ophthalmology, Balikesir, Izmir, Türkiye.
Background And Objective:
The aim of this study was to assess the impact of acromegaly and excessive growth hormone on ocular tissues using swept-source optical coherence tomography (SS-OCT).
Patients And Methods:
Subfoveal retinal thickness (SRT), subfoveal choroidal thicknesses (SCT), peripapillary retina nerve fiber layer (pRNFL), macular ganglion cell-inner plexiform complex (GCIPL), and scleral thickness were evaluated in this prospective study. Scleral thickness was evaluated in four quadrants at 2, 4, and 6 mm posterior to the scleral spur.
Results:
Right eyes of 50 acromegaly (Group 1) and 50 healthy individuals (Group 2) were enrolled. SRT was significantly higher in Group 1 (P = 0.036). SCT measurements showed no difference (P = 0.31). There was no difference between the groups in terms of pRNFL and GCIPL measurements (P = 0.30, P = 0.26). Thickness measurements from all scleral quadrants and all distances were significantly thicker in Group 1 than in Group 2 (P < 0.001).
Conclusion:
The study suggests the sclera may be a target tissue in acromegaly, with increased scleral thickness. No differences were found in choroidal, optic disc, or GCIPL parameters compared to controls.
