Related Experiment Video
Updated: Jul 29, 2026
Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
Published on: May 5, 2022
Tumor organoid and tumor-on-a-chip equipped next generation precision medicine
Wentao Zhao1, Zilin Zhang1, Shihui Xu2
1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, People's Republic of China.
Abstract:
Recently, significant advancements have been witnessed in variousin vitrotreatment evaluation models, especially organoids and organs-on-chips.In vitroculture of cancer cells and drug screening are key technical components in functional oncology precision medicine. However, most studies primarily focus on constructing models using established cell lines, with limited integration with clinical diagnosis or patient treatment. This review provides a brief overview of precision medicine models, followed by discussions on the broad spectrum of applications involving two-dimensional tumor cell culture, patient-derived tumor xenograft models, tumor organoids, and tumors-on-chips. It highlights the success rate of patient-derived tumor organoids construction and their application in clinical trials. Recent advancements in tumors-on-chips and organoids-on-chips are elaborated on, alongside with integration of other new generation technologies. Additionally, this review summarizes the advantages and constraints associated with tumor organoids and tumors-on-chips, underscoring their crucial role in the advancement of personalized medicine.
Insights
Organoids and organs-on-chips represent significant advancements in in vitro cancer treatment evaluation. These models are crucial for advancing precision medicine by improving drug screening and patient-specific treatment strategies.
Area of Science:
- Biomedical Engineering
- Oncology
- Regenerative Medicine
Background:
- Precision medicine in oncology relies heavily on accurate in vitro models for drug screening.
- Current models often use established cell lines, limiting direct clinical applicability.
- Organoids and organs-on-chips offer more physiologically relevant alternatives.
Purpose of the Study:
- To review the applications of various in vitro models in precision oncology.
- To highlight advancements in patient-derived tumor organoids and tumors-on-chips.
- To discuss the advantages and limitations of these models in personalized medicine.
Main Methods:
- Review of existing literature on in vitro cancer models.
- Discussion of two-dimensional cell culture, patient-derived xenografts, tumor organoids, and tumors-on-chips.
- Analysis of recent technological integrations and clinical trial successes.
Main Results:
- Patient-derived tumor organoids show high construction success rates and clinical trial applicability.
- Tumors-on-chips and organoids-on-chips demonstrate significant recent advancements.
- Integration with other technologies enhances the capabilities of these models.
Conclusions:
- Organoids and tumors-on-chips are vital for advancing personalized cancer medicine.
- These models offer improved drug screening and treatment evaluation compared to traditional methods.
- Further development is needed to overcome current constraints and maximize clinical impact.
More Related Videos
12:41Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis
Published on: December 23, 2022
07:31Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue
Published on: May 26, 2023
Related Concept Videos
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:27Tumor Immunotherapy