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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Exploring Potential Hub Genes and Molecular Mechanisms Linking Cardia Carcinoma With Sjögren's Syndrome Based on
Meng Qian1, Ying Chen1, Zhenxiang Wang1
1Department of Gastroenterology, Tongji Institute of Digestive Disease, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
The Journal of Gene Medicine
|September 25, 2025
Summary
This study identifies three key genes (E2F3, CHIA, SCNN1B) and a predictive model for cardia carcinoma (CC) in patients with Sjögren's syndrome (SS). These findings highlight potential immune-related mechanisms common to both conditions.
Area of Science:
- Oncology
- Genetics
- Immunology
Background:
- Cardia carcinoma (CC) is a growing global health concern.
- Gastroesophageal reflux disease is a known CC risk factor.
- Sjögren's syndrome (SS) patients often exhibit esophageal motility issues.
Purpose of the Study:
- Identify hub genes and molecular pathways common to CC and SS.
- Develop a predictive model for CC risk in SS patients.
Main Methods:
- Utilized Gene Expression Omnibus (GEO) datasets for analysis.
- Performed differential gene expression (DEGs) and weighted gene coexpression network analysis (WGCNA).
- Applied machine learning algorithms (RF, LASSO, SVM-RFE, XGBoost) to identify hub genes.
- Constructed and validated a nomogram for CC risk prediction.
Main Results:
- Identified 60 shared genes enriched in cell cycle, xenobiotic response, and p53 signaling pathways.
- Screened three hub genes (E2F3, CHIA, SCNN1B) and developed a highly accurate predictive nomogram (AUCtrain=0.991, AUCval=0.978).
- Found significant associations between hub genes and immune cells (T cells, B cells), suggesting a role for immune infiltration.
Conclusions:
- Identified E2F3, CHIA, and SCNN1B as key genes for CC in SS patients.
- Developed a validated nomogram for effective CC risk prediction in this cohort.
- Proposed that an unbalanced immune response is a shared pathogenic mechanism, offering new diagnostic and therapeutic avenues for CC with SS.
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