Diabetic encephalopathy models: A systematic review from cells to animals

Area of Science:

• Neuroscience
• Endocrinology
• Pathology

Background:

• Diabetic encephalopathy (DE) is a diabetes complication causing cognitive dysfunction, impacting learning and memory.
• DE incidence is rising globally, often exacerbated by coexisting Alzheimer's disease.
• Current understanding of DE pathogenesis is limited, hindering targeted therapy development.

Purpose of the Study:

• To review existing cell and animal models for diabetic encephalopathy research.
• To evaluate model selection based on research objectives and perspectives.
• To provide a reference for advancing DE pathogenesis understanding and drug development.

Main Methods:

• Literature review of cell and animal models for diabetic encephalopathy.
• Analysis of model advantages, limitations, and suitability for different research contexts.
• Evaluation of model selection rationale for specific research directions.

Main Results:

• Over ten distinct cell and animal models for DE have been developed.
• Each model presents unique strengths and weaknesses.
• Model suitability is context-dependent, varying with research goals.

Conclusions:

• Appropriate selection of cell and animal models is crucial for effective DE research.
• Understanding model characteristics aids in advancing DE pathogenesis studies.
• Improved model utilization can facilitate the development of novel therapeutic strategies for DE.