SGLT2-inhibitors and asthma outcomes in type 2 diabetes: Insights from a large multicenter study
A B M Nasibul Alam1, Natasha Gill2, Maram AlAshoor1
1Rosalind Franklin University/ Northwestern Medicine McHenry Hospital, 4201 Medical Centre Dr, McHenry, IL, 60050, USA.
Background:
Recent research suggests that SGLT2 inhibitors are associated with a decreased risk of asthma and may have therapeutic potential in reducing asthma severity. However, there is a paucity of data on how SGLT2 inhibitors might improve outcomes during asthma exacerbations in patients with type 2 diabetes.
Research Question:
Does the use of SGLT2 inhibitors improve 30-day outcomes after asthma exacerbation hospitalization in patients with type 2 diabetes?
Methods:
We conducted a retrospective cohort study using TriNetX, analyzing adults hospitalized for asthma exacerbation between 2015 and 2025. Patients with type 2 diabetes on SGLT2 inhibitors for at least three months were compared to those not on SGLT2 inhibitors. Outcomes included 30-day mortality, ICU admission, mechanical ventilation, and acute kidney injury (AKI).
Result:
After propensity score matching, SGLT2 inhibitor use was associated with significantly lower 30-day mortality. No statistically significant differences were observed for ICU admission, mechanical ventilation, or AKI between the groups.
Clinical Implication:
SGLT2 inhibitors could provide protective benefits and improve outcomes in asthma exacerbations for patients with type 2 diabetes, warranting further investigation in larger trials.
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