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Updated: Jan 16, 2026

Xenopus laevis as a Model to Identify Translation Impairment
Published on: September 27, 2015
RXFP1, the relaxin receptor: Lost and found in translation
Mark Lal1, Sean Eddy2, Anna Walentinsson3
1Bioscience, Cardiovascular, Renal and Metabolism, R&D Biopharmaceuticals, AstraZeneca, Gothenburg, Sweden.
Abstract:
Relaxin, historically recognized as a pregnancy hormone, is today characterized as a circulating protein possessing several cardiovascular modulating and anti-fibrotic properties of high clinical interest. Although it has long been recognized that there exists remarkable species diversity regarding the tissue sources and physiological effects of relaxin, there is a considerable gap in our translational understanding of its signal transducing receptor, relaxin family peptide receptor 1 (RXFP1). Here, we review the topic and highlight the striking contrast in RXFP1 tissue expression from rodents to humans, and describe how a renewed focus on RXFP1 target pharmacology is critical to delivering future clinical success in relation to this physiologically important signaling receptor.
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