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Real-World Adherence to Biologic Therapy for Severe Asthma in Children

Steven J Rose1, Aisaku Nakamura2, Md Monir Hossain3

  • 1Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

The Journal of Allergy and Clinical Immunology. in Practice
|September 25, 2025
PubMed

Insights

Pediatric severe asthma patients showed good adherence to biologic medications, improving symptoms and lung function. Adherence was linked to administration method, insurance, and dosing frequency, highlighting key factors for treatment success.

Area of Science:

  • Pediatric Pulmonology
  • Pharmacology
  • Asthma Management

Background:

  • Biologic medications are effective for severe asthma, but pediatric adherence data is limited.
  • Understanding adherence is crucial for optimizing treatment in children with severe asthma.

Purpose of the Study:

  • To assess adherence rates to biologic medications in children with severe asthma.
  • To identify factors influencing adherence and their impact on asthma outcomes.

Main Methods:

  • Retrospective chart review of pediatric patients with severe asthma.
  • Analysis of adherence during the first year of biologic therapy.
  • Statistical modeling to examine relationships between adherence, administration, insurance, dosing, and outcomes.

Main Results:

  • Adherence was 84% at 6 months and 76% at 12 months.
  • Administration method, insurance, and dosing frequency significantly impacted adherence.
  • Biologic therapy improved outcomes, with decreased exacerbations and improved spirometry (FVC, FEV1), which correlated with adherence.

Conclusions:

  • Pediatric adherence to asthma biologics exceeds that of inhaled corticosteroids.
  • Biologic therapies improve asthma control, and adherence is key to these benefits.
  • Administration strategy, insurance, and dosing are critical factors influencing adherence.
Abstract

Keywords:
AdherenceAsthmaBenralizumabBiologicChildrenDupilumabMepolizumabOmalizumabPediatricTezepelumab

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