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Updated: Jan 16, 2026

RNAi Trigger Delivery into Anopheles gambiae Pupae
Published on: March 8, 2016
REL2/NF-κB pathway modulates midgut bacterial homeostasis in Anopheles gambiae
1State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China.
Abstract:
A recent study by Zaković et al. demonstrates that disruption of REL2 in mosquitoes induces gut dysbiosis dominated by Serratia species, increases mosquito mortality after blood feeding, and unexpectedly reduces susceptibility to malaria infection. These findings reveal complex, functionally significant crosstalk between host immunity, gut microbiota, and the development of malaria parasites.
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