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Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
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OpenDose3D: A Free, Open-Source Clinical Dosimetry Software for Patient-Specific Dosimetry.

José-Alejandro Fragoso-Negrín1,2,3, Alex Vergara-Gil4, Assyifa Rahman Hakim5

  • 1Institut de Recherche en Cancérologie de Montpellier, Équipe Labellisée Ligue Contre le Cancer, INSERM U1194, Institut Régional du Cancer de Montpellier, Université de Montpellier, Montpellier, France.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|September 25, 2025
PubMed
Summary
This summary is machine-generated.

OpenDose3D (OD3D) is a new open-source software for nuclear medicine dosimetry. It enables standardized, patient-specific dosimetry by comparing different clinical workflows and providing research tools.

Keywords:
clinical dosimetry workflowsopen-source softwarepatient-specific dosimetryradionuclide therapyresearch methods

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Area of Science:

  • Medical Physics
  • Radiology
  • Computational Biology

Background:

  • Standardized clinical dosimetry practice in nuclear medicine is limited by the difficulty in comparing academic and commercial software tools.
  • There is a need for open-source, adaptable software for patient-specific dosimetry.

Purpose of the Study:

  • To introduce OpenDose3D (OD3D), an open-source software for image-based, patient-specific dosimetry in nuclear medicine.
  • To enable comparison of different dosimetry workflows and promote standardized practices.

Main Methods:

  • OD3D was developed as an extension of the 3D Slicer platform.
  • Key modules include calibration, absorbed dose rate calculation (3 algorithms), and time-dependent variable fitting.
  • Validation was performed using phantom data (MRTDosimetry) and challenge datasets (SNMMI Dosimetry Challenge 2021).

Main Results:

  • Phantom validation showed excellent agreement (<3% deviation) for calibration and organ dosimetry.
  • Tumor dosimetry differences were linked to pharmacokinetic modeling.
  • OD3D results for the SNMMI Dosimetry Challenge dataset (patient A) showed absolute z scores < 1.

Conclusions:

  • The OpenDose collaboration offers free dosimetry tools and data.
  • OD3D serves as a research tool for clinical dosimetry, professional education, and benchmarking of dosimetry software.