Related Experiment Video

Updated: Jan 16, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

15.9K

Correlation between polymorphisms of the aquaporin-1 gene and peritoneal function in children on chronic peritoneal

Jiani Yao1,2, Chunyan Wang1, Xiaoyan Fang1

  • 1Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.

Pediatric Nephrology (Berlin, Germany)
|September 25, 2025
PubMed

Insights

Genetic variations in Aquaporin-1 (AQP1) influence peritoneal dialysis outcomes. Specific AQP1 polymorphisms, rs2075574 and rs1049305, correlate with altered ultrafiltration and urea transport in pediatric patients undergoing peritoneal dialysis (PD).

Area of Science:

  • Nephrology
  • Genetics
  • Molecular Biology

Background:

  • Aquaporins (AQPs) facilitate water transport across cell membranes.
  • Aquaporin-1 (AQP1) plays a role in cellular water permeability.
  • Understanding AQP1 genetic variations is crucial for optimizing treatments in kidney disease.

Purpose of the Study:

  • To investigate the association between AQP1 gene polymorphisms and peritoneal function in children undergoing peritoneal dialysis (PD).
  • To identify specific AQP1 genotypes that may predict treatment efficacy or complications in pediatric PD patients.

Main Methods:

  • A cohort of 187 children on chronic PD was analyzed.
  • Four AQP1 polymorphisms (rs2075574, rs1049305, rs10253374, rs17159702) were genotyped.
  • Peritoneal equilibration test (PET) parameters, including ultrafiltration and urea transport (pKT/V), were assessed.

Main Results:

  • The TT genotype for AQP1 rs2075574 was linked to lower baseline ultrafiltration compared to the CC genotype.
  • The CC genotype for AQP1 rs1049305 showed higher pKT/V values.
  • At 12-month follow-up, AQP1 rs1049305 CC and CG genotypes were associated with increased PET ultrafiltration compared to the GG genotype.
  • No significant correlation was found between the studied AQP1 genotypes and adverse events.

Conclusions:

  • AQP1 rs2075574 and rs1049305 polymorphisms are potentially associated with variations in ultrafiltration and urea transport efficiency in children on PD.
  • These findings suggest a genetic basis for individual differences in PD outcomes.
  • Further research is warranted to explore the clinical implications of these AQP1 variants in pediatric nephrology.
Abstract

Keywords:
ChildrenGenetic polymorphismPeritoneal dialysisPeritoneal function

More Related Videos

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

3.1K
Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

10.2K

Related Concept Videos

Aquaporins01:25

Aquaporins

Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
6.1K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
549
Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
2.4K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
3.1K
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
665
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
1.6K