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Related Experiment Video

Updated: Jan 16, 2026

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
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Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

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RGS2-Related Non-coding Interaction Network Modulates the NF-Kappa B Signaling Pathway in MS Patients: A Systems

Parisa Forouzanfar1, Mohammad Hashemian1, Mojdeh Mahmoudian1,2

  • 1Zist Fanavari Novin Biotechnology Institute, Isfahan, Iran.

Journal of Molecular Neuroscience : MN
|September 25, 2025
PubMed
Summary
This summary is machine-generated.

This study identifies novel RNA biomarkers, NCK1-DT and ASH1L-AS1, for multiple sclerosis (MS). These long non-coding RNAs, along with RGS2, may impact the NF-Kappa B signaling pathway in MS patients.

Keywords:
BioinformaticsLong non-coding RNAMicroarray analysisMultiple sclerosis

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Area of Science:

  • Neuroimmunology
  • Molecular Biology
  • Bioinformatics

Background:

  • Multiple sclerosis (MS) is a prevalent chronic inflammatory neurological disorder affecting millions globally.
  • Understanding the molecular mechanisms, particularly RNA dysregulation, in MS is crucial for developing diagnostic tools and therapeutic strategies.

Purpose of the Study:

  • To identify novel dysregulated RNAs and elucidate their regulatory networks in multiple sclerosis.
  • To explore the potential of identified RNAs as diagnostic biomarkers for MS.
  • To investigate the involvement of these RNAs in MS-related signaling pathways.

Main Methods:

  • Analysis of high-throughput gene expression datasets using R Studio.
  • Exploration of miRNA, lncRNA, and protein interactions via miRWalk and lncRRIsearch.
  • Pathway enrichment analysis using Enrichr and KEGG, with qRT-PCR validation.

Main Results:

  • Significant upregulation of RGS2 mRNA in MS patients.
  • Identification of novel lncRNAs, NCK1-DT and ASH1L-AS1, with elevated expression in MS.
  • Discovery of regulatory interactions involving miR-4638-3p, miR-4525, RGS2, NCK1-DT, and ASH1L-AS1 within a ceRNA network.
  • Association of RGS2 with the NF-Kappa B signaling pathway.

Conclusions:

  • NCK1-DT and ASH1L-AS1 are proposed as novel diagnostic biomarkers for MS.
  • The identified lncRNAs may influence MS pathogenesis by modulating the NF-Kappa B signaling pathway through interactions with RGS2 mRNA.