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Updated: Jan 16, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Inhibitors of Epigenetic Modulators as Therapeutic Alternatives for Cardiovascular Diseases

Gustavo A Barraza1, Wendy Rosales2, Carlos Meléndez1

  • 1Organic and Biomedical Chemistry Research Group, Faculty of Basic Sciences, Universidad del Atlántico, Barranquilla, Colombia.

Mini Reviews in Medicinal Chemistry
|September 26, 2025
PubMed

Insights

Cardiovascular diseases remain a leading cause of death. Epigenetic modulators, like DNA methyltransferases (DNMTs) inhibitors, offer new therapeutic strategies for treating heart disease.

Area of Science:

  • Cardiovascular Medicine
  • Epigenetics
  • Pharmacology

Background:

  • Cardiovascular diseases (CVDs) are the primary global cause of mortality.
  • Current treatments struggle to halt CVD progression.
  • Epigenetic mechanisms are increasingly recognized as crucial in CVD development.

Purpose of the Study:

  • To review the mechanisms of epigenetic modulators.
  • To explore the therapeutic potential of epigenetic modulators in cardiovascular diseases.
  • To highlight novel treatment strategies targeting epigenetic modifications.

Main Methods:

  • Review of scientific literature on epigenetics and cardiovascular diseases.
  • Analysis of DNA methylation and histone modification patterns in CVDs.
  • Examination of natural and synthetic inhibitors of epigenetic modulators.

Main Results:

  • Epigenetic alterations, including DNA methylation and histone modifications, are linked to cardiovascular pathologies.
  • Inhibitors of epigenetic modulators, particularly DNA methyltransferases (DNMTs), show promise.
  • These inhibitors represent a potential new therapeutic avenue for cardiovascular diseases.

Conclusions:

  • Epigenetic modulation offers a promising frontier for novel cardiovascular therapies.
  • Targeting epigenetic mechanisms like DNA methylation could provide alternative treatment strategies.
  • Further research into DNMT inhibitors and other epigenetic modulators is warranted for CVD management.
Keywords:
Cardiovascular diseasesDNA methylastionbiomedical researchepigenetic mechanismsepigenetic modulatorsinhibitors

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