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HCV infection: Extrahepatic manifestations of infection and treatment options

Krzysztof Simon1,2, Monika Pazgan-Simon2

  • 1Department of Infectious Diseases and Hepatology, Faculty of Medicine, Wroclaw Medical University, Poland.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|September 26, 2025
PubMed

Insights

Hepatitis C virus (HCV) infection impacts multiple organs, causing extrahepatic manifestations (EHMs) in 30-40% of patients. Viral elimination leading to sustained virological response (SVR) is key for treating both liver disease and EHMs.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis C virus (HCV) infection is a systemic disease with significant extrahepatic manifestations (EHMs).
  • EHMs affect 30-40% of HCV-infected individuals, often linked to immunological factors or direct viral impact.
  • EHMs typically occur alongside liver disease, highlighting the systemic nature of HCV.

Keywords:
HCVlivermixed cryoglobulinemia

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