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PANoptosis: A novel therapeutic target in kidney disease (Review)

Lianyan Jiang1, Liangbin Zhao2, Yu Liu3

  • 1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.

International Journal of Molecular Medicine
|September 26, 2025
PubMed

Insights

PANoptosis, a cell death pathway involving pyroptosis, apoptosis, and necroptosis, is increasingly linked to kidney disease progression. Understanding PANoptosis mechanisms offers new therapeutic targets for kidney failure.

Area of Science:

  • Nephrology
  • Cell Biology
  • Immunology

Background:

  • Global kidney disease prevalence is rising, leading to renal failure and increased mortality.
  • Understanding kidney disease pathophysiology and identifying therapeutic targets are critical public health priorities.
  • Cell death pathways significantly influence the progression of kidney diseases.

Purpose of the Study:

  • To review the mechanisms of PANoptosis, a novel programmed cell death pathway.
  • To explore the role of PANoptosis in the development of various kidney diseases.
  • To discuss potential diagnostic and therapeutic strategies targeting PANoptosis in nephrology.

Main Methods:

  • Literature review of current research on PANoptosis.
  • Analysis of studies investigating PANoptosis in kidney disease models.
  • Synthesis of evidence linking PANoptosis to renal pathophysiology.

Main Results:

  • PANoptosis integrates pyroptosis, apoptosis, and necroptosis via the PANoptosome complex.
  • Evidence suggests PANoptosis plays a significant role in the pathogenesis of kidney diseases.
  • Dysregulation of PANoptosis contributes to progressive kidney function decline.

Conclusions:

  • PANoptosis is a key player in kidney disease development and progression.
  • Targeting PANoptosis pathways may offer novel therapeutic avenues for kidney diseases.
  • Further research into PANoptosis regulation is essential for advancing kidney disease treatment.
Keywords:
PANoptosisapoptosiskidney diseasenecroptosispyroptosis

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