An Argument for Decentralized Clinical Trials in Gynecologic Oncology
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View abstract on PubMed
Summary
This summary is machine-generated.Distance to the cancer center and receiving chemotherapy locally were key factors influencing enrollment in advanced ovarian cancer prehabilitation trials. Addressing these barriers could improve clinical trial access.
Area Of Science
- Oncology
- Clinical Trials
- Health Services Research
Background
- Clinical trial enrollment is crucial for advancing cancer care.
- Understanding factors influencing enrollment in ovarian cancer trials is essential.
- Prehabilitation interventions show promise for improving patient outcomes.
Purpose Of The Study
- To identify demographic, clinical, and social determinants of health influencing clinical trial enrollment in advanced ovarian cancer patients.
- To compare characteristics of patients enrolled versus not enrolled in a prehabilitation trial.
Main Methods
- Retrospective analysis of patients with advanced ovarian cancer approached for a prehabilitation trial.
- Comparison of demographic, clinical, and social determinants of health between enrolled and non-enrolled groups.
- Statistical analysis to identify significant factors associated with enrollment decisions.
Main Results
- No significant differences in most demographic and clinical characteristics were observed.
- Greater distance to the study institution was associated with non-enrollment (42.2% vs 21.9% living >=200 miles away, P<.05).
- Patients receiving neoadjuvant chemotherapy within the study institution were more likely to enroll (81.2% vs 53.1%, P=.02).
Conclusions
- Geographic distance and chemotherapy treatment location are significant barriers to clinical trial enrollment.
- Decentralizing clinical trials and offering local treatment options may improve access for ovarian cancer patients.
- Addressing social determinants of health, like travel burden, is vital for equitable clinical trial participation.
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