Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.6K
The pathophysiology of pneumonia involves the following steps:
2.6K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

824
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
824
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.2K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

691
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
691
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

10.9K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
10.9K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AKT Signaling Differentially Regulates the Expression of Two Evolutionarily Conserved <i>Wnt5a</i> Isoforms in Lung Mesenchymal Cells.

Cells·2026
Same author

An Advanced Single-Cell RNA Sequencing (scRNA-seq) Protocol Utilizing Custom-Designed Multiplexing.

Bio-protocol·2026
Same author

MLKL Regulates Intracellular Trafficking of Neutrophil Elastase to Promote Lung Epithelial Cell Senescence.

American journal of respiratory cell and molecular biology·2026
Same author

PDLIM2 repression: a common mechanism in viral lung infection.

ImmunoHorizons·2026
Same author

Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity.

Cell reports·2026
Same author

Alveolar epithelial NF-κB/RelA guards the lung against bacterial infection.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Jan 16, 2026

Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection
08:02

Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection

Published on: September 19, 2025

436

PDLIM2 Repression: A Common Mechanism in Viral Lung Infection.

Feng Gao1, Yongzheng W Chen2, Steven D Shapiro3

  • 1Department of Molecular Microbiology and Immunology, Hastings Center for Pulmonary Research, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA.

Biorxiv : the Preprint Server for Biology
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

PDLIM2 protein expression decreases during viral infections like SARS-CoV-2 and influenza, correlating with disease severity. This repression impacts immune cell function and suggests PDLIM2 as a biomarker for viral diseases.

Keywords:
InfluenzaNF-kBPDLIM2 repressionSARS-CoV-2Viral Lung Infection

More Related Videos

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.5K
Isolation of Mouse Lung Dendritic Cells
09:04

Isolation of Mouse Lung Dendritic Cells

Published on: November 22, 2011

29.8K

Related Experiment Videos

Last Updated: Jan 16, 2026

Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection
08:02

Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection

Published on: September 19, 2025

436
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.5K
Isolation of Mouse Lung Dendritic Cells
09:04

Isolation of Mouse Lung Dendritic Cells

Published on: November 22, 2011

29.8K

Area of Science:

  • Immunology
  • Molecular Biology
  • Virology

Background:

  • PDLIM2 is a tumor suppressor and immune modulator, inhibiting NF-κB and STAT3 transcription factors.
  • Its role in viral infections is not well understood.
  • PDLIM2 is highly expressed in lung and immune cells.

Purpose of the Study:

  • To investigate the role of PDLIM2 in human viral infections.
  • To analyze PDLIM2 expression in response to SARS-CoV-2 and influenza infections.
  • To explore the association between PDLIM2 expression and immune signaling pathways.

Main Methods:

  • Analysis of public gene expression data from human blood, bronchoalveolar lavage, and lung tissues.
  • Comparison of PDLIM2 expression in uninfected individuals versus those infected with SARS-CoV-2 or influenza.
  • Correlation analysis of PDLIM2 expression with NF-κB and STAT3 activity.

Main Results:

  • Viral infection repressed PDLIM2 expression in various immune and lung cells.
  • Reduced PDLIM2 expression correlated with increased disease severity.
  • Low PDLIM2 levels were associated with aberrant activation of NF-κB and STAT3 signaling pathways.

Conclusions:

  • PDLIM2 repression is a common mechanism in human viral infectious diseases.
  • PDLIM2 may serve as a potential biomarker for disease prognosis.
  • Targeting PDLIM2 could offer therapeutic strategies for viral infections.