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The progress of miR-205 regulating apoptosis in cancer

Dandan Chai1, Hua Du2,3, Yingxu Shi1

  • 1Department of Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Frontiers in Oncology
|September 26, 2025
PubMed

Insights

MicroRNAs (miRNAs) regulate genes and are crucial in cancer. This review details how miR-205 impacts apoptosis, showing dual roles in cancer progression and potential therapeutic uses.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
  • miRNA dysregulation is linked to human cancer pathogenesis.
  • miR-205 shows aberrant expression in various cancers, affecting tumor initiation and progression.

Purpose of the Study:

  • To review the functional role of miR-205 in apoptosis regulation in human malignancies.
  • To explore the dual oncogenic and tumor-suppressive functions of miR-205.
  • To highlight miR-205's therapeutic potential in cancer treatment.

Main Methods:

  • Systematic literature review of recent advances.
  • Analysis of miR-205's role in apoptosis-related signaling pathways.
  • Examination of miR-205's downstream target genes.

Main Results:

  • miR-205 exhibits a dual role in regulating apoptosis in cancer cells.
  • It modulates key apoptosis pathways and target genes.
  • Aberrant miR-205 expression contributes to both oncogenic and tumor-suppressive functions.

Conclusions:

  • miR-205 plays a complex role in apoptosis, influencing cancer development.
  • Understanding miR-205's function is critical for developing novel cancer therapies.
  • miR-205 represents a promising therapeutic target for various human malignancies.
Keywords:
apoptosiscancermiR-205microRNAprogrammed cell death

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