Polypoid Müllerianosis Mimicking Primary Gynecologic Malignancy

Müllerianosis is the ectopic presence of at least two distinct müllerian-derived tissues in extrauterine sites. This case report explores its origin, diagnosis, and treatment strategies.

We report a biopsy-proven case of polypoid müllerianosis in the left distal ureter and parametrium, causing severe hydroureteronephrosis. Initial imaging raised concern for malignancy; however, histopathologic examination confirmed a benign lesion-polypoid müllerianosis. The patient underwent a modified radical hysterectomy with partial ureteral resection and reimplantation to relieve the obstruction and resect the affected segment en bloc with the primary gynecologic mass.

This case highlights the importance of a multidisciplinary approach in diagnosing rare conditions such as polypoid müllerianosis. Collaborative efforts between gynecologists, urologists, and pathologists are essential for accurate diagnosis and optimal treatment planning.