Different Colours of Polycythemia Vera: A Case Series

Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by increased red blood cell mass, often with leukocytosis and thrombocytosis, predisposing to thrombotic and hemorrhagic events. We report three cases with varied presentations: a 38-year-old man with headaches, dizziness, blurred vision, and fatigue; a 54-year-old woman with acute myocardial infarction; and a 60-year-old man with acute ischemic stroke. All had elevated hemoglobin/hematocrit, low erythropoietin, and positive JAK2 mutation. Management with phlebotomy, hydroxyurea, and supportive measures led to good recovery. These cases illustrate the spectrum of PV manifestations, emphasizing early diagnosis and treatment to reduce morbidity and mortality.