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[Rhesus factor distribution in the families of hypophyseal nanism patients]
The author examined 211 members of 57 families with a genetic (familial) and idiopathic (sporadic) hypophysial nanism of obscure genesis. Rh-negative blood or weakened varieties of the Rh-antigen were revealed in 71 of 211 persons (33.1%), in 44 of 57 families (77.2%). Heterozygotic character of the majority of the positive parents of the sick children, by the Rh-factor, is undoubtful. Analysis of the Rh-factor distribution and of the antigens of the ABO system in the families suffering from hypophysial nanism permitted to exclude the significance of the hematological conflict by these antigens between the mother and the fetus, as a determining factor. It is supposed that there is a possible pathogenetic association between the hypophysial nanism and the absence of the Rh-antigen which is inherited also as an autosomic-recessive sign.
The author examined 211 members of 57 families with a genetic (familial) and idiopathic (sporadic) hypophysial nanism of obscure genesis. Rh-negative blood or weakened varieties of the Rh-antigen were revealed in 71 of 211 persons (33.1%), in 44 of 57 families (77.2%). Heterozygotic character of the majority of the positive parents of the sick children, by the Rh-factor, is undoubtful. Analysis of the Rh-factor distribution and of the antigens of the ABO system in the families suffering from hypophysial nanism permitted to exclude the significance of the hematological conflict by these antigens between the mother and the fetus, as a determining factor. It is supposed that there is a possible pathogenetic association between the hypophysial nanism and the absence of the Rh-antigen which is inherited also as an autosomic-recessive sign.