Related Experiment Video
Updated: Jan 16, 2026

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Published on: May 20, 2016
Advancements in nasal drug delivery system of natural products
Yenna Hsu1,2, Jiajing Yang1,2, Miaoyang Cao1,2
1Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background:
Nasal drug delivery offers a non-invasive route with rapid absorption and the ability to bypass first-pass metabolism, making it promising for central nervous system (CNS) disorders, nasal diseases such as allergic rhinitis, and other chronic conditions by enabling targeted delivery and crossing the blood-brain barrier.
Purpose:
To review the advantages of nasal delivery, therapeutic potential of natural products, and how drug delivery systems may overcome bioavailability and solubility issues.
Study Design:
A literature review analyzing mechanisms, clinical applications, and limitations of natural products in nasal delivery.
Methods:
Relevant articles published before January 2025 were retrieved from Google Scholar, PubMed, ScienceDirect, Scopus, Web of Science, Springer, and official sources.
Results:
Nasal administration improves the bioavailability and absorption of natural products, enhancing anti-inflammatory, antioxidant, neuroprotective, and anti-allergic effects. However, poor solubility and stability remain barriers, which may be mitigated by nanocarriers, liposomes, and other advanced systems.
Conclusion:
Combining nasal drug delivery with natural products is a promising strategy for treating CNS, nasal, and chronic diseases, potentially improving clinical efficacy and expanding therapeutic options.
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