Related Experiment Video
Updated: Jan 16, 2026
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
Circulatory cathepsin K as biomarkers in older adults with sarcopenia: a case-control study
Huaqing Liu1, Hongdou Liu2, Yan Xing1
1Department of Gastroenterology, Nanyang Central Hospital, Nanyang, Henan, China.
Background:
This study explores the relationship between circulating cathepsin K (CatK) and cathepsin D (CatD) levels and sarcopenia in older adults.
Methods:
This case-control study included 343 participants aged more than 65 from Nanyang Central Hospital. Sarcopenia was diagnosed using AWGS criteria, requiring low handgrip strength (HGS) and reduced appendicular skeletal muscle mass (ASM). Fasting blood samples were collected to measure CatD and CatK levels via ELISA. The study compared these levels between groups and evaluated their diagnostic value using ROC curve analysis.
Results:
Serum CatK levels were significantly higher in participants with low HGS, low ASM, and sarcopenia (all p < 0.05). CatK negatively correlated with HGS (β = -0.899, p = 0.016) and showed diagnostic value with an AUROC of 0.704 for sarcopenia. CatD levels showed no significant differences or correlations. The optimal CatK cutoff for sarcopenia was 5.53 ng/mL, with high CatK associated with increased odds of low HGS (OR = 1.895, p = 0.014) and sarcopenia (OR = 3.926, p < 0.001).
Conclusion:
Circulating CatK is a promising biomarker for sarcopenia, offering potential for early diagnosis and therapeutic targeting.
More Related Videos
14:39Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
04:00Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
Published on: July 26, 2024
Related Concept Videos
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...