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Comparative Evaluation of Incidence of Cardiovascular Events Among Different Drug-Eluting Stent Features: A
Hossein Koushki1,2, Reza Golchin Vafa1,3, Reza Heydarzadeh1,3
1Shiraz University of Medical Sciences Shiraz Iran.
Insights
Major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) were linked to heart failure, hypertension, and lower ejection fraction. Stent number and length also predicted MACE, but stent type did not impact outcomes over 5 years.
Area of Science:
- Cardiology
- Interventional Cardiology
- Biomedical Engineering
Background:
- Coronary artery disease (CAD) management frequently involves percutaneous coronary intervention (PCI).
- Diverse stent types are utilized in PCI, potentially influencing patient outcomes.
- A comprehensive understanding of long-term MACE associated with different stent types is crucial for clinical decision-making.
Purpose of the Study:
- To compare major adverse cardiovascular events (MACE) in patients undergoing PCI with various drug-eluting stent types.
- To identify patient and procedural factors associated with MACE over a 5-year follow-up period post-PCI.
Main Methods:
- Retrospective cohort study analyzing Iranian PCI patient data.
- Inclusion criteria focused on drug-eluting stent recipients, excluding emergency surgical cases.
- Cox regression analyses were employed to assess predictors of MACE.
Main Results:
- Over 5 years, 10.2% of patients experienced MACE.
- Significant MACE predictors included heart failure history, hypertension, lower ejection fraction, increased number of stents, and longer total stent length.
- No significant association was observed between specific drug-eluting stent types and MACE.
Conclusions:
- Drug-eluting stent type did not significantly influence 5-year MACE rates post-PCI.
- Patient factors like heart failure and hypertension, along with procedural factors such as stent number and length, are key determinants of MACE.
Background And Aims:
Coronary artery disease (CAD) is often treated with percutaneous coronary intervention (PCI). Various stent types are used during PCI, potentially resulting in different outcomes. Here, we compared major adverse cardiovascular events (MACE) across different stents over a 5-year follow-up post-PCI.
Methods:
This retrospective cohort study analyzed individuals receiving PCI from Iranian databases. Inclusion criteria encompassed drug-eluting stent recipients, excluding emergency surgical cases. Demographics, medical history, angiography, PCI details, and follow-up on MACE were collected and analyzed using Cox regression analyses.
Results:
Out of 4159 recruited patients, MACE were observed in 10.2% of individuals over 5 years. Factors significantly associated with MACE included a history of heart failure (HR: 2.58, 95% CI: 1.92-3.47), hypertension (HR: 1.87, 95% CI: 1.52-2.30), and lower baseline ejection fraction (HR: 0.975, 95% CI: 0.952-0.997). Procedural elements like the number of stents used (HR: 1.008, 95% CI: 1.005-1.012) and their total length (HR: 1.008, 95% CI: 1.005-1.012) were also significant predictors. No significant relationship was found between the types of drug-eluting stents and MACE.
Conclusion:
In a 5-year study of post-PCI patients, MACE rates were higher in those with lower ejection fractions and those with more stented vessels and longer stents but similar across different drug-eluting stents.
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